![]() ![]() Muscle pain is the most common complaint among patients taking statins, and statin intolerance is most commonly related to myalgia, or muscle pain. The side effect profiles of statins are very similar with more severity of symptoms common in hydrophilic forms of statins due to more medication penetrating the muscle tissue. There are two classes of statins: 1) Hydrophobic (non-water soluble) and 2) Hydrophilic (water soluble). Statins are a group of medications that have the same mechanism of action of lowering cholesterol through inhibiting its production in the liver. What side effects are commonly associated with statin medications? Statin medications help reduce the total cholesterol level in patients, which is calculated by adding together the LDL and HDL levels and combining them with 20 percent of the triglyceride level. Although you want to keep levels of HDL high, it’s better to have low levels of LDL, since LDL is the substance that contributes to the development of plaque buildup in the blood vessels. However, good cholesterol, or HDL, is actually a good thing to have high levels of, as this type of cholesterol helps absorb LDL and transport it to the liver, which removes it from the body. Reduced blood flow is associated with a higher risk of experiencing heart disease, heart attack, and stroke, so it’s important to keep cholesterol levels in check. Plaque buildup along the walls of the blood vessels causes the blood vessels to narrow, reducing blood flow to and from the heart, organs, brain, and extremities. Most people have more LDL in their bodies than HDL, which can cause plaque to build up on the walls of the blood vessels when the imbalance gets too large. LDL cholesterol, also known as bad cholesterol, and HDL cholesterol, also known as good cholesterol, impact the total cholesterol level in the body. The body contains two types of cholesterol, both of which are impacted by the use of statin medications. Lower levels of LDL cholesterol and triglycerides are associated with a lower risk of heart attack, stroke, and other cardiovascular events in patients with type 2 diabetes, coronary heart disease, and other risk factors. Statin medications can also help to reduce the levels of triglycerides, a type of fat that is found in the blood. In addition to reducing the production of cholesterol overall, statin medications also help to increase the level of “good” cholesterol, called high-density lipoprotein or HDL, in conjunction with lifestyle changes. Statins primarily work to reduce cholesterol by acting on the levels of LDL, or “bad” cholesterol in the blood. Statin medications are used to treat high levels of cholesterol in the blood. What are statin medications used to treat? As a result of lower levels of cholesterol, the substance is less likely to cause the buildup of plaque along the walls of the blood vessels, which allows blood to flow freely from the heart to the brain, extremities, and organs. Statin medications work by decreasing the amount of cholesterol produced by the liver. Statin medications are commonly used to lower levels of low-density lipoprotein, or LDL, cholesterol, which is the type of cholesterol that can cause damage to the blood vessels and cardiovascular system. Although the medications belong to a class of prescription drugs called HMG CoA reductase inhibitors, they are more commonly referred to as statins due to the names of the medications. ![]() Statin medications are among the most commonly prescribed medications in the world. So, which statin medication has the least amount of side effects, and can statin medication side effects be mitigated? What are statin medications? ![]() Unfortunately, high cholesterol levels can be life threatening because they increase your risk of experiencing heart disease, heart attack, and stroke due to the buildup of plaque in the blood vessels of the body. No one wants to experience unpleasant side effects as a result of their medication, but statins have a particularly high rate of intolerance. Concern about the side effects of statin medications, which are commonly used to treat high cholesterol, is widespread. Although many people in the United States could benefit from medication to manage their high cholesterol, only about 55 percent of those patients are currently taking the medication. According to the Center for Disease Control and Prevention (CDC), an estimated 95 million American adults currently suffer from high cholesterol (total cholesterol levels of 200 mg/dL or higher), while 29 million American adults suffer from very high cholesterol (total cholesterol level of 240 mg/dL or higher). ![]()
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